Bayesian Estimation of the Inbreeding Coefficient for Single Nucleotide Polymorphism Using Complex Survey Data
نویسنده
چکیده
Title of Document: BAYESIAN ESTIMATION OF THE INBREEDING COEFFICIENT FOR SINGLE NUCLEOTIDE POLYMORPHISM USING COMPLEX SURVEY DATA Zhenyi Xue, Doctor of Philosophy, 2015 Directed By: Professor Partha Lahiri Associate Professor Yan Li Joint Program in Survey Methodology In genome-wide association studies (GWAS), single nucleotide polymorphism (SNP) is often used as a genetic marker to study gene-disease association. Some large scale health sample surveys have recently started collecting genetic data. There is now growing interest in developing statistical procedures using genetic survey data. This calls for innovative statistical methods that incorporate both genetic and statistical
منابع مشابه
Run of Homozygosity a Procedure to Detecting Inbreeding in Farm Animals
Inbreeding depression is a harmful phenomenon in livestock which is outcome of inbreeding. Inbreeding is consequence mating between two individuals who are more related to each other than average relatedness in population, which results in reducing in fitness of progenies and genetic variability in populations. Development of high-density genome-wide single nucleotide polymorphism (SNP) array f...
متن کاملA Bayesian Nominal Regression Model with Random Effects for Analysing Tehran Labor Force Survey Data
Large survey data are often accompanied by sampling weights that reflect the inequality probabilities for selecting samples in complex sampling. Sampling weights act as an expansion factor that, by scaling the subjects, turns the sample into a representative of the community. The quasi-maximum likelihood method is one of the approaches for considering sampling weights in the frequentist framewo...
متن کاملAccuracy of Genomic Prediction under Different Genetic Architectures and Estimation Methods
The accuracy of genomic breeding value prediction was investigated in various levels of reference population size, trait heritability and the number of quantitative trait locus (QTL). Five Bayesian methods, including Bayesian Ridge regression, BayesA, BayesB, BayesC and Bayesian LASSO, were used to estimate the marker effects for each of 27 scenarios resulted from combining three levels for her...
متن کاملInbreeding Effect on Genetic Parameters of Economic Traits in Moghani Sheep Breed
The aim of this study was to investigate the effect of inbreeding on the estimation of genetic parameters of weight traits at different ages in Moghani sheep. In the present study, the information of 11721 Moghani sheep in Jafarabad Moghan breeding station from 1987 to 2011 was used. Genetic parameters were estimated using single trait model with covariate and classification and without inbree...
متن کاملEstimation of genotype imputation accuracy using reference populations with varying degrees of relationship and marker density panel
Genotype imputation from low-density to high-density (SNP) chips is an important step before applying genomic selection, because denser chips can provide more reliable genomic predictions. In the current research, the accuracy of genotype imputation from low and moderate-density panels (5K and 50K) to high-density panels in the purebred and crossbred populations was assessed. The simulated popu...
متن کامل